NAD+ Therapy 101

Nicotinamide adenine dinucleotide (NAD+): a critical coenzyme found in every cell in your body and involved in hundreds of metabolic processes.

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a naturally occurring coenzyme found in virtually every cell. Its function is to help catalyse reactions in the body and is heavily involved in cell regeneration, DNA repair, cell metabolism and the production of cellular energy. Unfortunately, this invaluable compound rapidly declines with age1.

 

How does NAD+ Therapy help?

Emerging evidence suggests that higher NAD+ levels may slow or even reverse aspects of aging and age-related diseases, including obesity, diabetes, cardiovascular diseases and neurodegenerative conditions2. This is because as NAD+ levels drop, the pathways that NAD+ operate become compromised leading to accelerated aging and a greater risk for developing a range of diseases. Numerous clinical trials have been published on NAD+ Therapy and it is typically very well-tolerated5. Side effects are rare and usually mild, such as flushing.

 

NAD+ Mechanisms:

  1. May contribute to longer telomeres for anti-aging
  2. Promotes DNA repair
  3. Modulates immune-cell signaling
  4. Improves mental clarity, focus and concentration
  5. Boosts mood
  6. Mitigates chemical stress inflammation
  7. Activates sirtuins3
  8. Supports energy production4

 

What People are Saying?

“Fountain of youth molecule” – Dr. David Sinclair, Ph.D, Professor in Department of Genetics, Harvard Medical School

 

“Potentially one of the greatest advances in medical science since the invention of penicillin.”- Dr. Phillip Milgram, Scripps Memorial Hospital

 

“The next big anti-aging drug” – Dr. Ross Grant, Australasian Research Institute

References

  1. Schultz MB, Sinclair DA. Why NAD(+) Declines during Aging: It’s Destroyed. Cell Metab. 2016;23(6):965‐ doi:10.1016/j.cmet.2016.05.022
  2. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
  3. Blander G, Guarente L (2004). “The Sir2 family of protein deacetylases.” Annu. Rev. Biochem. 73: 417–35.
  4. Bürkle A (2005). “Poly(ADP-ribose). The most elaborate metabolite of NAD+.” FEBS J. 272 (18): 4576–89.
  5. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
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